The Influence Of Adeno Associated Virus Vector Receptor AAVR And Co-Receptors And Their Mutations On Tropism And Transduction Of Adeno Associated Virus During Gene Therapy A Review Tirthal Rai Usha Adiga Deepika Kamath M

Gene therapy is an experimental treatment being investigated to correct defective genes that are responsible for disease development. To treat cancer and genetic illnesses, researchers looking into a variety of gene techniques. Finding proper vector transfer DNA tissues one the most difficult aspects therapy. Some vectors have issues with infecting both quiescent dividing cells, provoking immunological response, lack indefinite expression, reproducible high titre. The adenovirus, retrovirus, recombinant modified adeno-associated virus top contenders (rAAV). may be resolved by adeno associated (AAV). Hemophilia condition which benefited using AAV as vector. Aim this review emphasize on role receptors(AAVR) co-receptors in tropism transduction virus(AAV) hemophilia In Vitro well Vivo.